I have an 04 Pacifica and it came up with a P0353 code. Which appears to be a malfunction with the ignition coil on cylinder #3. I removed the coil and swapped it with another coil. Cleared the computer and started it back up. Got the same code. I did this 3 times. All the coils i tried, work on the other cylinders but not #3. Also I replaced all the spark plugs as well and even swapped the plug in #3 multiple times to eliminate that as the issue. I am at a loss. No matter which coil or plug is in cylinder #3 it will come up with P0353 code and runs very rough like it is misfiring. Please Help.

 

I have not worked on my ignition system so I don't have hands on experience. But I looked at my manual a bit. I would carefully inspect the coil wire harness for number three. Early in the troubleshooting steps they have you attach a spark tester and check for normal spark at the offending coil. You could have all good coils and plugs, but are getting no power to the coil, or not enough. Fuel supply is the next culprit on the list if you can eliminate an ignition issue. Good luck.